Dean and Sam retrieve the Colt from the demon Crowley that informs that Lucifer is in Carthage. The Winchester brothers head with Castiel, Jo and Ellen to the town expecting to defeat the devil. Castiel sees many invisible reapers in town, and Bobby tells that Lucifer will summon the Death. However Lucifer traps Castiel, and Meg sends invisible hound dogs to catch them. When Jo is deadly wounded and trapped in a store with her mother and the Winchester brothers, they plot a suicidal plan to kill Lucifer.